F10. GUT MICROBIOTA-RELATED PHENOLIC METABOLITES ACROSS COMPARTMENTS – IMPLICATIONS FOR SCHIZOPHRENIA

Clinical application of gut microbiota metabolites: A novel opportunity in personalized medicine

Nowadays, metabolomics studies are performed with different approaches to identify biomarkers, clarify the underlying mechanisms of diseases and achieve novel treatment strategies. In this context, gut microbiota-derived metabolites are known as one of the most important mediators of gut microbiota effects on human health and various diseases. Due to the inefficiency of conventional therapies i...

Gut Microbiota and Neuropsychiatric Disorders

Tryptophan: A gut microbiota-derived metabolites regulating inflammation

Inflammatory bowel diseases (IBD), which comprise Crohn's disease and ulcerative colitis, are chronic intestinal disorders with an increased prevalence and incidence over the last decade in many different regions over the world. The etiology of IBD is still not well defined, but evidence suggest that it results from perturbation of the homeostasis between the intestinal microbiota and the mucos...

Ecophysiological consequences of alcoholism on human gut microbiota: implications for ethanol-related pathogenesis of colon cancer

Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effects of chronic ethanol consumption on the human gut microbiome are poorly under...

Effects of gut microbiota on the brain: implications for psychiatry.

It may be surprising to learn that the human gastrointestinal tract is home to 1014 bacterial organisms. In fact, there are more bacteria in the gut than there are somatic cells in the body. These resident bacteria are referred to as commensal microbiota, and their arrival during the first few postnatal days sets up a symbiotic association that is necessary and crucial to normal physiology. Thi...